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Chemical IN04 Inhibits the Kinase Domain not the ROC Domain of LRRK1: Results from Homology Modeling and Molecular Docking
BACKGROUND: Bone loss is the most common reason for broken bones among the elderly. An ideal agent for treatment of bone loss should have both osteoclast inhibitory and osteoblast stimulatory functions. Leucine rich repeat kinase 1 (LRRK1) is a novel target for alternative anti-resorptive drugs to t...
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| Publicat a: | Med Chem |
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| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2021
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7987913/ https://ncbi.nlm.nih.gov/pubmed/32972350 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/1573406416666200924125620 |
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