HC‐HA/PTX3 from amniotic membrane reverts senescent limbal niche cells to Pax6+ neural crest progenitors to support limbal epithelial progenitors

Quiescence and self‐renewal of human corneal epithelial progenitor/stem cells (LEPC) are regulated by the limbal niche, presumably through close interaction with limbal (stromal) niche cells (LNC). Paired box homeotic gene 6 (Pax6), a conserved transcription factor essential for eye development, is...

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Vydáno v:Stem Cells
Hlavní autoři: Chen, Szu‐Yu, Zhu, Yingting, Zhang, Yuan, Hsu, David, Tseng, Scheffer C.G.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley & Sons, Inc. 2021
Témata:
Regenerative Medicine
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7986837/
https://ncbi.nlm.nih.gov/pubmed/33373496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.3323
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