HC-HA/PTX3 Purified From Human Amniotic Membrane Reverts Human Corneal Fibroblasts and Myofibroblasts to Keratocytes by Activating BMP Signaling

PURPOSE: Fibrosis or scarring is a pathological outcome of wound healing and is characterized by terminally differentiated myofibroblasts. Heavy chain-hyaluronic acid/pentraxin 3 (HC-HA/PTX3) is a unique matrix component purified from amniotic membrane that exerts an anti-inflammatory effect. Herein...

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Udgivet i:Invest Ophthalmol Vis Sci
Main Authors: Zhu, Ying-Ting, Li, Fu, Zhang, Yuan, Chen, Szu-Yu, Tighe, Sean, Lin, Shin-Ying, Tseng, Scheffer C. G.
Format: Artigo
Sprog:Inglês
Udgivet: The Association for Research in Vision and Ophthalmology 2020
Fag:
Cornea
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7405802/
https://ncbi.nlm.nih.gov/pubmed/32462202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.61.5.62
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