Induced hepatic stellate cell integrin, α8β1, enhances cellular contractility and TGFβ activity in liver fibrosis

No effective therapy exists for fatal fibrosis. New therapeutic targets are needed for hepatic fibrosis because the incidence keeps increasing. The activation and differentiation of fibroblasts into myofibroblasts that causes excessive matrix deposition is central to fibrosis. Here, we investigated...

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Dettagli Bibliografici
Pubblicato in:J Pathol
Autori principali: Nishimichi, Norihisa, Tsujino, Kazuyuki, Kanno, Keishi, Sentani, Kazuhiro, Kobayashi, Tsuyoshi, Chayama, Kazuaki, Sheppard, Dean, Yokosaki, Yasuyuki
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley & Sons, Ltd 2021
Soggetti:
Brief Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7986747/
https://ncbi.nlm.nih.gov/pubmed/33433924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.5618
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