Osteopontin Undergoes Polymerization in Vivo and Gains Chemotactic Activity for Neutrophils Mediated by Integrin α9β1

Osteopontin (OPN) is an integrin-binding inflammatory cytokine that undergoes polymerization catalyzed by transglutaminase 2. We have previously reported that polymeric OPN (polyOPN), but not unpolymerized OPN (OPN*), attracts neutrophils in vitro by presenting an acquired binding site for integrin...

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Detalhes bibliográficos
Main Authors: Nishimichi(西, Norihisa, 道教尚), Hayashita-Kinoh(早, Hiromi, 下- 喜納裕美), Chen, Chun, Matsuda(松, Haruo, 田治男), Sheppard, Dean, Yokosaki(横, Yasuyuki, 崎恭之)
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Glycobiology and Extracellular Matrices
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3064171/
https://ncbi.nlm.nih.gov/pubmed/21321126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.189258
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