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Polymeric Osteopontin Employs Integrin α9β1 as a Receptor and Attracts Neutrophils by Presenting a de Novo Binding Site

Osteopontin (OPN) is a cytokine and ligand for multiple members of the integrin family. OPN undergoes the in vivo polymerization catalyzed by cross-linking enzyme transglutaminase 2, which consequently increases the bioactivity through enhanced interaction with integrins. The integrin α9β1, highly e...

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Bibliografiske detaljer
Main Authors: Nishimichi, Norihisa, Higashikawa, Fumiko, Kinoh, Hiromi H., Tateishi, Yoshiko, Matsuda, Haruo, Yokosaki, Yasuyuki
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2685658/
https://ncbi.nlm.nih.gov/pubmed/19346516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M901515200
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