Induced hepatic stellate cell integrin, α8β1, enhances cellular contractility and TGFβ activity in liver fibrosis

No effective therapy exists for fatal fibrosis. New therapeutic targets are needed for hepatic fibrosis because the incidence keeps increasing. The activation and differentiation of fibroblasts into myofibroblasts that causes excessive matrix deposition is central to fibrosis. Here, we investigated...

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Detalhes bibliográficos
Publicado no:J Pathol
Main Authors: Nishimichi, Norihisa, Tsujino, Kazuyuki, Kanno, Keishi, Sentani, Kazuhiro, Kobayashi, Tsuyoshi, Chayama, Kazuaki, Sheppard, Dean, Yokosaki, Yasuyuki
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2021
Assuntos:
Brief Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7986747/
https://ncbi.nlm.nih.gov/pubmed/33433924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.5618
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