Induced hepatic stellate cell integrin, α8β1, enhances cellular contractility and TGFβ activity in liver fibrosis

No effective therapy exists for fatal fibrosis. New therapeutic targets are needed for hepatic fibrosis because the incidence keeps increasing. The activation and differentiation of fibroblasts into myofibroblasts that causes excessive matrix deposition is central to fibrosis. Here, we investigated...

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Bibliografiske detaljer
Udgivet i:J Pathol
Main Authors: Nishimichi, Norihisa, Tsujino, Kazuyuki, Kanno, Keishi, Sentani, Kazuhiro, Kobayashi, Tsuyoshi, Chayama, Kazuaki, Sheppard, Dean, Yokosaki, Yasuyuki
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley & Sons, Ltd 2021
Fag:
Brief Report
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7986747/
https://ncbi.nlm.nih.gov/pubmed/33433924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.5618
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