Establishment of an in vitro model for analyzing mitochondrial ultrastructure in PRKN-mutated patient iPSC-derived dopaminergic neurons

Mitochondrial structural changes are associated with the regulation of mitochondrial function, apoptosis, and neurodegenerative diseases. PRKN is known to be involved with various mechanisms of mitochondrial quality control including mitochondrial structural changes. Parkinson’s disease (PD) with PR...

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Bibliographische Detailangaben
Veröffentlicht in:Mol Brain
Hauptverfasser: Yokota, Mutsumi, Kakuta, Soichiro, Shiga, Takahiro, Ishikawa, Kei-ichi, Okano, Hideyuki, Hattori, Nobutaka, Akamatsu, Wado, Koike, Masato
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2021
Schlagworte:
Methodology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7986497/
https://ncbi.nlm.nih.gov/pubmed/33757554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13041-021-00771-0
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