Escape from Pluripotency via Inhibition of TGF-β/BMP and Activation of Wnt Signaling Accelerates Differentiation and Aging in hPSC Progeny Cells

Human pluripotent stem cells (hPSCs) represent a potentially valuable cell source for applications in cell replacement therapy, drug development, and disease modeling. For all these uses, it is necessary to develop reproducible and robust protocols for differentiation into desired cell types. Howeve...

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Veröffentlicht in:Stem Cell Reports
Hauptverfasser: Fujimori, Koki, Matsumoto, Takuya, Kisa, Fumihiko, Hattori, Nobutaka, Okano, Hideyuki, Akamatsu, Wado
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5831048/
https://ncbi.nlm.nih.gov/pubmed/29107593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stemcr.2017.09.024
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