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Engineering synthetic morphogen systems that can program multicellular patterning

In metazoan tissues, cells decide their fates by sensing positional information provided by specialized morphogen proteins. To explore what features are sufficient for positional encoding, we asked whether arbitrary molecules (e.g., green fluorescent protein or mCherry) could be converted into synth...

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Pubblicato in:Science
Autori principali: Toda, Satoshi, McKeithan, Wesley L., Hakkinen, Teemu J., Lopez, Pilar, Klein, Ophir D., Lim, Wendell A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7986291/
https://ncbi.nlm.nih.gov/pubmed/33060357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.abc0033
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