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Base editing strategy for insertion of the A673T mutation in the APP gene to prevent the development of AD in vitro
The amyloid precursor protein (APP) is a transmembrane protein mostly found in neurons. Cleavage of this protein by β-secretase can lead to the formation of amyloid-β (Aβ) peptide plaque, which leads to Alzheimer’s disease. Genomic analysis of an Icelandic population that did not show symptoms of Al...
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| Pubblicato in: | Mol Ther Nucleic Acids |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society of Gene & Cell Therapy
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7985668/ https://ncbi.nlm.nih.gov/pubmed/33815938 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2021.02.032 |
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