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Rarity of the Alzheimer Disease–Protective APP A673T Variant in the United States
IMPORTANCE: Recently, a rare variant in the amyloid precursor protein gene (APP) was described in a population from Iceland. This variant, in which alanine is replaced by threonine at position 673 (A673T), appears to protect against late-onset Alzheimer disease (AD). We evaluated the frequency of th...
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Publicat a: | JAMA Neurol |
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Autors principals: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Format: | Artigo |
Idioma: | Inglês |
Publicat: |
2015
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Matèries: | |
Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4324097/ https://ncbi.nlm.nih.gov/pubmed/25531812 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2014.2157 |
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