Genome-wide linkage analyses of non-Hispanic White families identifies novel loci for familial late-onset Alzheimer's disease

INTRODUCTION: Few high penetrance variants that explain risk in Late-onset Alzheimer's disease (LOAD) families have been found. METHODS: We performed genomewide linkage and identity-by-descent (IBD) analyses on 41 non-Hispanic Caucasian families exhibiting likely dominant inheritance of LOAD, a...

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Publicado no:Alzheimers Dement
Principais autores: Kunkle, Brian W., Jaworski, James, Barral, Sandra, Vardarajan, Badri, Beecham, Gary W., Martin, Eden R., Cantwell, Laura S., Partch, Amanda, Bird, Thomas D., Raskind, Wendy H., DeStefano, Anita L., Carney, Regina M., Cuccaro, Michael, Vance, Jeffrey M., Farrer, Lindsay A., Goate, Alison M., Foroud, Tatiana, Mayeux, Richard P., Schellenberg, Gerard D., Haines, Jonathan L., Pericak-Vance, Margaret A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4717829/
https://ncbi.nlm.nih.gov/pubmed/26365416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jalz.2015.05.020
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