Genome-wide linkage analyses of non-Hispanic White families identifies novel loci for familial late-onset Alzheimer's disease

INTRODUCTION: Few high penetrance variants that explain risk in Late-onset Alzheimer's disease (LOAD) families have been found. METHODS: We performed genomewide linkage and identity-by-descent (IBD) analyses on 41 non-Hispanic Caucasian families exhibiting likely dominant inheritance of LOAD, a...

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Veröffentlicht in:Alzheimers Dement
Hauptverfasser: Kunkle, Brian W., Jaworski, James, Barral, Sandra, Vardarajan, Badri, Beecham, Gary W., Martin, Eden R., Cantwell, Laura S., Partch, Amanda, Bird, Thomas D., Raskind, Wendy H., DeStefano, Anita L., Carney, Regina M., Cuccaro, Michael, Vance, Jeffrey M., Farrer, Lindsay A., Goate, Alison M., Foroud, Tatiana, Mayeux, Richard P., Schellenberg, Gerard D., Haines, Jonathan L., Pericak-Vance, Margaret A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4717829/
https://ncbi.nlm.nih.gov/pubmed/26365416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jalz.2015.05.020
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