Base editing strategy for insertion of the A673T mutation in the APP gene to prevent the development of AD in vitro

The amyloid precursor protein (APP) is a transmembrane protein mostly found in neurons. Cleavage of this protein by β-secretase can lead to the formation of amyloid-β (Aβ) peptide plaque, which leads to Alzheimer’s disease. Genomic analysis of an Icelandic population that did not show symptoms of Al...

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Bibliographic Details
Published in:Mol Ther Nucleic Acids
Main Authors: Guyon, Antoine, Rousseau, Joël, Bégin, Francis-Gabriel, Bertin, Tom, Lamothe, Gabriel, Tremblay, Jacques P.
Format: Artigo
Language:Inglês
Published: American Society of Gene & Cell Therapy 2021
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7985668/
https://ncbi.nlm.nih.gov/pubmed/33815938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2021.02.032
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