Focused ultrasound mediated blood–brain barrier opening is safe and feasible in a murine pontine glioma model

Drug delivery in diffuse intrinsic pontine glioma is significantly limited by the blood-brain barrier (BBB). Focused ultrasound (FUS), when combined with the administration of microbubbles can effectively open the BBB permitting the entry of drugs across the cerebrovasculature into the brainstem. Gi...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Englander, Zachary K., Wei, Hong-Jian, Pouliopoulos, Antonios N., Bendau, Ethan, Upadhyayula, Pavan, Jan, Chia-Ing, Spinazzi, Eleanora F., Yoh, Nina, Tazhibi, Masih, McQuillan, Nicholas M., Wang, Tony J. C., Bruce, Jeffrey N., Canoll, Peter, Feldstein, Neil A., Zacharoulis, Stergios, Konofagou, Elisa E., Wu, Cheng-Chia
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7985134/
https://ncbi.nlm.nih.gov/pubmed/33753753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-021-85180-y
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