DDEL-13. FOCUSED ULTRASOUND MEDIATED BLOOD BRAIN BARRIER DISRUPTION IN A MURINE MODEL OF PONTINE GLIOMA: A SAFETY AND FEASIBILITY STUDY

BACKGROUND: Drug delivery remains a major obstacle in DIPG, as the blood brain barrier (BBB) limits the penetration of systemic therapies to the brainstem. Focused ultrasound (FUS) is an exciting new technology that, when combined with microbubbles, can open the BBB permitting the entry of drugs acr...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Englander, Zachary, Wei, Hong-Jian, Pouliopoulos, Antonios, Upadhyayula, Pavan, Jan, Chia-Ing, Spinazzi, Eleonora, Canoll, Peter, Bruce, Jeffrey, Feldstein, Neil, Zacharoulis, Stergios, Konofagou, Elisa, Wu, Cheng-Chia
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Drug Delivery/Pharmacokinetics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715592/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.048
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