DDEL-13. FOCUSED ULTRASOUND MEDIATED BLOOD BRAIN BARRIER DISRUPTION IN A MURINE MODEL OF PONTINE GLIOMA: A SAFETY AND FEASIBILITY STUDY

BACKGROUND: Drug delivery remains a major obstacle in DIPG, as the blood brain barrier (BBB) limits the penetration of systemic therapies to the brainstem. Focused ultrasound (FUS) is an exciting new technology that, when combined with microbubbles, can open the BBB permitting the entry of drugs acr...

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Detalles Bibliográficos
Publicado en:Neuro Oncol
Main Authors: Englander, Zachary, Wei, Hong-Jian, Pouliopoulos, Antonios, Upadhyayula, Pavan, Jan, Chia-Ing, Spinazzi, Eleonora, Canoll, Peter, Bruce, Jeffrey, Feldstein, Neil, Zacharoulis, Stergios, Konofagou, Elisa, Wu, Cheng-Chia
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2020
Assuntos:
Drug Delivery/Pharmacokinetics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7715592/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noaa222.048
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