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Truncation- and motif-based pan-cancer analysis reveals tumor-suppressing kinases
A major challenge in cancer genomics is identifying “driver” mutations from the many neutral “passenger” mutations within a given tumor. To identify driver mutations that would otherwise be lost within mutational noise, we filtered genomic data by motifs that are critical for kinase activity. In the...
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| Udgivet i: | Sci Signal |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7984728/ https://ncbi.nlm.nih.gov/pubmed/29666306 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aan6776 |
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