Somatically mutated ABL1 is an actionable and essential NSCLC survival gene

The lack of actionable mutations in patients with non‐small cell lung cancer (NSCLC) presents a significant hurdle in the design of targeted therapies for this disease. Here, we identify somatically mutated ABL1 as a genetic dependency that is required to maintain NSCLC cell survival. We demonstrate...

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Detalhes bibliográficos
Publicado no:EMBO Mol Med
Main Authors: Testoni, Ewelina, Stephenson, Natalie L, Torres‐Ayuso, Pedro, Marusiak, Anna A, Trotter, Eleanor W, Hudson, Andrew, Hodgkinson, Cassandra L, Morrow, Christopher J, Dive, Caroline, Brognard, John
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
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Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4734836/
https://ncbi.nlm.nih.gov/pubmed/26758680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201505456
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