Effects of the Dual Endothelin Receptor Antagonist Aprocitentan on Body Weight and Fluid Homeostasis in Healthy Subjects on a High Sodium Diet

Aprocitentan is a novel, oral, dual endothelin receptor antagonist (ERA) in development in difficult‐to‐control hypertension. As fluid retention and edema are concerns with ERAs, we investigated whether aprocitentan causes weight gain in healthy subjects on a high sodium diet and explored potential...

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Bibliografske podrobnosti
izdano v:Clin Pharmacol Ther
Main Authors: Gueneau de Mussy, Pierre, Sidharta, Patricia N., Wuerzner, Gregoire, Maillard, Marc P., Guérard, Nicolas, Iglarz, Marc, Flamion, Bruno, Dingemanse, Jasper, Burnier, Michel
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2020
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7984323/
https://ncbi.nlm.nih.gov/pubmed/32897570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpt.2043
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