Plasma and cerebrospinal fluid pharmacokinetics of select chemotherapeutic agents following intranasal delivery in a non-human primate model

The blood–brain barrier (BBB) limits entry of most chemotherapeutic agents into the CNS, resulting in inadequate exposure within CNS tumor tissue. Intranasal administration is a proposed means of delivery that can bypass the BBB, potentially resulting in more effective chemotherapeutic exposure at t...

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Veröffentlicht in:J Neurooncol
Hauptverfasser: League-Pascual, James C., Lester-McCully, Cynthia M., Shandilya, Shaefali, Ronner, Lukas, Rodgers, Louis, Cruz, Rafael, Peer, Cody J., Figg, William D., Warren, Katherine E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7983166/
https://ncbi.nlm.nih.gov/pubmed/28290002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11060-017-2388-x
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