PI3Kδ Forms Distinct Multiprotein Complexes at the TCR Signalosome in Naïve and Differentiated CD4(+) T Cells

Phosphoinositide 3-kinases (PI3Ks) play a central role in adaptive immunity by transducing signals from the T cell antigen receptor (TCR) via production of PIP(3). PI3Kδ is a heterodimer composed of a p110δ catalytic subunit associated with a p85α or p85β regulatory subunit and is preferentially eng...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Luff, Daisy H., Wojdyla, Katarzyna, Oxley, David, Chessa, Tamara, Hudson, Kevin, Hawkins, Phillip T., Stephens, Len R., Barry, Simon T., Okkenhaug, Klaus
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7982423/
https://ncbi.nlm.nih.gov/pubmed/33763075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2021.631271
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