Coincident signals from GPCRs and receptor tyrosine kinases are uniquely transduced by PI3Kβ in myeloid cells

Class I phosphoinositide 3-kinases (PI3Ks) catalyze production of the lipid messenger phosphatidylinositol 3,4,5-trisphosphate (PIP(3)), which plays a central role in a complex signaling network regulating cell growth, survival, and movement. This network is overactivated in cancer and inflammation,...

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Bibliographic Details
Published in:Sci Signal
Main Authors: Houslay, Daniel M., Anderson, Karen E., Chessa, Tamara, Kulkarni, Suhasini, Fritsch, Ralph, Downward, Julian, Backer, Jonathan M., Stephens, Len R., Hawkins, Phillip T.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5417692/
https://ncbi.nlm.nih.gov/pubmed/27531651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aae0453
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