Metabolic profiling of angiopoietin-like protein 3 and 4 inhibition: a drug-target Mendelian randomization analysis

AIMS : Angiopoietin-like protein 3 (ANGPTL3) and 4 (ANGPTL4) inhibit lipoprotein lipase (LPL) and represent emerging drug targets to lower circulating triglycerides and reduce cardiovascular risk. To investigate the molecular effects of genetic mimicry of ANGPTL3 and ANGPTL4 inhibition and compare t...

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Detaylı Bibliyografya
Yayımlandı:Eur Heart J
Asıl Yazarlar: Wang, Qin, Oliver-Williams, Clare, Raitakari, Olli T, Viikari, Jorma, Lehtimäki, Terho, Kähönen, Mika, Järvelin, Marjo-Riitta, Salomaa, Veikko, Perola, Markus, Danesh, John, Kettunen, Johannes, Butterworth, Adam S, Holmes, Michael V, Ala-Korpela, Mika
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2020
Konular:
Clnical Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7982288/
https://ncbi.nlm.nih.gov/pubmed/33351885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurheartj/ehaa972
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