Metabolic profiling of angiopoietin-like protein 3 and 4 inhibition: a drug-target Mendelian randomization analysis

AIMS : Angiopoietin-like protein 3 (ANGPTL3) and 4 (ANGPTL4) inhibit lipoprotein lipase (LPL) and represent emerging drug targets to lower circulating triglycerides and reduce cardiovascular risk. To investigate the molecular effects of genetic mimicry of ANGPTL3 and ANGPTL4 inhibition and compare t...

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Udgivet i:Eur Heart J
Main Authors: Wang, Qin, Oliver-Williams, Clare, Raitakari, Olli T, Viikari, Jorma, Lehtimäki, Terho, Kähönen, Mika, Järvelin, Marjo-Riitta, Salomaa, Veikko, Perola, Markus, Danesh, John, Kettunen, Johannes, Butterworth, Adam S, Holmes, Michael V, Ala-Korpela, Mika
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2020
Fag:
Clnical Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7982288/
https://ncbi.nlm.nih.gov/pubmed/33351885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurheartj/ehaa972
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