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Alternative binding modes in abortive NADH-alcohol complexes of horse liver alcohol dehydrogenase

Enzymes typically have high specificity for their substrates, but the structures of substrates and products differ, and multiple modes of binding are observed. In this study, high resolution X-ray crystallography of complexes with NADH and alcohols show alternative modes of binding in the active sit...

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Publicat a:Arch Biochem Biophys
Autors principals: Plapp, Bryce V., Ramaswamy, S.
Format: Artigo
Idioma:Inglês
Publicat: 2021
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7980771/
https://ncbi.nlm.nih.gov/pubmed/33675814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2021.108825
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