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Inversion of substrate stereoselectivity of horse liver alcohol dehydrogenase by substitutions of Ser-48 and Phe-93

The substrate specificities of alcohol dehydrogenases (ADH) are of continuing interest for understanding the physiological functions of these enzymes. Ser-48 and Phe-93 have been identified as important residues in the substrate binding sites of ADHs, but more comprehensive structural and kinetic st...

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Detalhes bibliográficos
Publicado no:Chem Biol Interact
Main Authors: Kim, Keehyuk, Plapp, Bryce V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5481492/
https://ncbi.nlm.nih.gov/pubmed/28025168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2016.12.016
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