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Alternative binding modes in abortive NADH-alcohol complexes of horse liver alcohol dehydrogenase

Enzymes typically have high specificity for their substrates, but the structures of substrates and products differ, and multiple modes of binding are observed. In this study, high resolution X-ray crystallography of complexes with NADH and alcohols show alternative modes of binding in the active sit...

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Detalhes bibliográficos
Publicado no:Arch Biochem Biophys
Main Authors: Plapp, Bryce V., Ramaswamy, S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7980771/
https://ncbi.nlm.nih.gov/pubmed/33675814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.abb.2021.108825
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