Cytokine receptor clustering in sensory neurons with an engineered cytokine fusion protein triggers unique pain resolution pathways

New therapeutic approaches to resolve persistent pain are highly needed. We tested the hypothesis that manipulation of cytokine receptors on sensory neurons by clustering regulatory cytokine receptor pairs with a fusion protein of interleukin (IL)-4 and IL-10 (IL4–10 FP) would redirect signaling pat...

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發表在:Proc Natl Acad Sci U S A
Main Authors: Prado, Judith, Westerink, Remco H. S., Popov-Celeketic, Jelena, Steen-Louws, Cristine, Pandit, Aridaman, Versteeg, Sabine, van de Worp, Wouter, Kanters, Deon H. A. J., Reedquist, Kris A., Koenderman, Leo, Hack, C. Erik, Eijkelkamp, Niels
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2021
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7980471/
https://ncbi.nlm.nih.gov/pubmed/33836560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2009647118
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