FcαRI Dynamics Are Regulated by GSK-3 and PKCζ During Cytokine Mediated Inside-Out Signaling

IgA binding to FcαRI (CD89) is rapidly enhanced by cytokine induced inside-out signaling. Dephosphorylation of serine 263 in the intracellular tail of FcαRI by PP2A and PI3K activation are instrumental in this process. To further investigate these signaling pathways, we targeted downstream kinases o...

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Publicado en:Front Immunol
Main Authors: ten Broeke, Toine, Honing, Henk, Brandsma, Arianne M., Jacobino, Shamir, Bakema, Jantine E., Kanters, Deon, van der Linden, Jan A. M., Bracke, Madelon, Koenderman, Leo, Leusen, Jeanette H. W.
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6365424/
https://ncbi.nlm.nih.gov/pubmed/30766540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.03191
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