Desmin aggrephagy in rat and human ischemic heart failure through PKCζ and GSK3β as upstream signaling pathways

Post-translational modifications of cardiac proteins could participate to left contractile dysfunction resulting in heart failure. Using a rat model of ischemic heart failure, we showed an accumulation of phosphorylated desmin leading to toxic aggregates in cardiomyocytes, but the cellular mechanism...

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Détails bibliographiques
Publié dans:Cell Death Discov
Auteurs principaux: Bouvet, Marion, Dubois-Deruy, Emilie, Turkieh, Annie, Mulder, Paul, Peugnet, Victoriane, Chwastyniak, Maggy, Beseme, Olivia, Dechaumes, Arthur, Amouyel, Philippe, Richard, Vincent, Lamblin, Nicolas, Pinet, Florence
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2021
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC8257599/
https://ncbi.nlm.nih.gov/pubmed/34226534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41420-021-00549-2
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