FcαRI Dynamics Are Regulated by GSK-3 and PKCζ During Cytokine Mediated Inside-Out Signaling

IgA binding to FcαRI (CD89) is rapidly enhanced by cytokine induced inside-out signaling. Dephosphorylation of serine 263 in the intracellular tail of FcαRI by PP2A and PI3K activation are instrumental in this process. To further investigate these signaling pathways, we targeted downstream kinases o...

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Udgivet i:Front Immunol
Main Authors: ten Broeke, Toine, Honing, Henk, Brandsma, Arianne M., Jacobino, Shamir, Bakema, Jantine E., Kanters, Deon, van der Linden, Jan A. M., Bracke, Madelon, Koenderman, Leo, Leusen, Jeanette H. W.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6365424/
https://ncbi.nlm.nih.gov/pubmed/30766540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.03191
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