Sialic Acid-Engineered IL4–10 Fusion Protein is Bioactive and Rapidly Cleared from the Circulation

PURPOSE: Modulating sialylation of therapeutic glycoproteins may be used to influence their clearance and systemic exposure. We studied the effect of low and high sialylated IL4–10 fusion protein (IL4–10 FP) on in vitro and in vivo bioactivity and evaluated the effect of differential sialylation on...

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Опубликовано в: :Pharm Res
Главные авторы: Steen-Louws, Cristine, Boross, Peter, Prado, Judith, Meeldijk, Jan, Langenhorst, Jurgen B., Huitema, Alwin D. R., den Hartog, Marcel T., Boon, Louis, Lafeber, Floris P. J. G., Hack, C. Erik, Eijkelkamp, Niels, Popov-Celeketic, Jelena
Формат: Artigo
Язык:Inglês
Опубликовано: Springer US 2019
Предметы:
Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6932964/
https://ncbi.nlm.nih.gov/pubmed/31879800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-019-2744-y
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