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Sialic Acid-Engineered IL4–10 Fusion Protein is Bioactive and Rapidly Cleared from the Circulation

PURPOSE: Modulating sialylation of therapeutic glycoproteins may be used to influence their clearance and systemic exposure. We studied the effect of low and high sialylated IL4–10 fusion protein (IL4–10 FP) on in vitro and in vivo bioactivity and evaluated the effect of differential sialylation on...

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מידע ביבליוגרפי
הוצא לאור ב:	Pharm Res
Main Authors:	Steen-Louws, Cristine, Boross, Peter, Prado, Judith, Meeldijk, Jan, Langenhorst, Jurgen B., Huitema, Alwin D. R., den Hartog, Marcel T., Boon, Louis, Lafeber, Floris P. J. G., Hack, C. Erik, Eijkelkamp, Niels, Popov-Celeketic, Jelena
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Springer US 2019
נושאים:	Research Paper
גישה מקוונת:	https://ncbi.nlm.nih.gov/pmc/articles/PMC6932964/ https://ncbi.nlm.nih.gov/pubmed/31879800 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-019-2744-y
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Sialic Acid-Engineered IL4–10 Fusion Protein is Bioactive and Rapidly Cleared from the Circulation

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