Cytokine receptor clustering in sensory neurons with an engineered cytokine fusion protein triggers unique pain resolution pathways

New therapeutic approaches to resolve persistent pain are highly needed. We tested the hypothesis that manipulation of cytokine receptors on sensory neurons by clustering regulatory cytokine receptor pairs with a fusion protein of interleukin (IL)-4 and IL-10 (IL4–10 FP) would redirect signaling pat...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Prado, Judith, Westerink, Remco H. S., Popov-Celeketic, Jelena, Steen-Louws, Cristine, Pandit, Aridaman, Versteeg, Sabine, van de Worp, Wouter, Kanters, Deon H. A. J., Reedquist, Kris A., Koenderman, Leo, Hack, C. Erik, Eijkelkamp, Niels
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2021
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7980471/
https://ncbi.nlm.nih.gov/pubmed/33836560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2009647118
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge