Sialic Acid-Engineered IL4–10 Fusion Protein is Bioactive and Rapidly Cleared from the Circulation

PURPOSE: Modulating sialylation of therapeutic glycoproteins may be used to influence their clearance and systemic exposure. We studied the effect of low and high sialylated IL4–10 fusion protein (IL4–10 FP) on in vitro and in vivo bioactivity and evaluated the effect of differential sialylation on...

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Pubblicato in:Pharm Res
Autori principali: Steen-Louws, Cristine, Boross, Peter, Prado, Judith, Meeldijk, Jan, Langenhorst, Jurgen B., Huitema, Alwin D. R., den Hartog, Marcel T., Boon, Louis, Lafeber, Floris P. J. G., Hack, C. Erik, Eijkelkamp, Niels, Popov-Celeketic, Jelena
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer US 2019
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6932964/
https://ncbi.nlm.nih.gov/pubmed/31879800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-019-2744-y
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