β2-adrenoceptor ligand efficacy is tuned by a two-stage interaction with the Gαs C terminus

Classical pharmacological models have incorporated an “intrinsic efficacy” parameter to capture system-independent effects of G protein–coupled receptor (GPCR) ligands. However, the nonlinear serial amplification of downstream signaling limits quantitation of ligand intrinsic efficacy. A recent biop...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Kim, Keehun, Paulekas, Shayla, Sadler, Fredrik, Gupte, Tejas M., Ritt, Michael, Dysthe, Matthew, Vaidehi, Nagarajan, Sivaramakrishnan, Sivaraj
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2021
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7980469/
https://ncbi.nlm.nih.gov/pubmed/33836582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2017201118
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