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β2-adrenoceptor ligand efficacy is tuned by a two-stage interaction with the Gαs C terminus
Classical pharmacological models have incorporated an “intrinsic efficacy” parameter to capture system-independent effects of G protein–coupled receptor (GPCR) ligands. However, the nonlinear serial amplification of downstream signaling limits quantitation of ligand intrinsic efficacy. A recent biop...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7980469/ https://ncbi.nlm.nih.gov/pubmed/33836582 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2017201118 |
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