The pentapeptide-repeat protein, MfpA, interacts with mycobacterial DNA gyrase as a DNA T-segment mimic

DNA gyrase, a type II topoisomerase, introduces negative supercoils into DNA using ATP hydrolysis. The highly effective gyrase-targeted drugs, fluoroquinolones (FQs), interrupt gyrase by stabilizing a DNA-cleavage complex, a transient intermediate in the supercoiling cycle, leading to double-strande...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Feng, Lipeng, Mundy, Julia E. A., Stevenson, Clare E. M., Mitchenall, Lesley A., Lawson, David M., Mi, Kaixia, Maxwell, Anthony
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2021
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7980463/
https://ncbi.nlm.nih.gov/pubmed/33836580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2016705118
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