The Pentapeptide Repeat Proteins MfpA(Mt) and QnrB4 Exhibit Opposite Effects on DNA Gyrase Catalytic Reactions and on the Ternary Gyrase-DNA-Quinolone Complex

MfpA(Mt) and QnrB4 are two newly characterized pentapeptide repeat proteins (PRPs) that interact with DNA gyrase. The mfpA(Mt) gene is chromosome borne in Mycobacterium tuberculosis, while qnrB4 is plasmid borne in enterobacteria. We expressed and purified the two PRPs and compared their effects on...

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Bibliografiske detaljer
Main Authors: Mérens, Audrey, Matrat, Stéphanie, Aubry, Alexandra, Lascols, Christine, Jarlier, Vincent, Soussy, Claude-James, Cavallo, Jean-Didier, Cambau, Emmanuelle
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2009
Fag:
Genetics and Molecular Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2648189/
https://ncbi.nlm.nih.gov/pubmed/19060136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.01205-08
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