The Pentapeptide Repeat Proteins MfpA(Mt) and QnrB4 Exhibit Opposite Effects on DNA Gyrase Catalytic Reactions and on the Ternary Gyrase-DNA-Quinolone Complex

MfpA(Mt) and QnrB4 are two newly characterized pentapeptide repeat proteins (PRPs) that interact with DNA gyrase. The mfpA(Mt) gene is chromosome borne in Mycobacterium tuberculosis, while qnrB4 is plasmid borne in enterobacteria. We expressed and purified the two PRPs and compared their effects on...

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Detalhes bibliográficos
Main Authors: Mérens, Audrey, Matrat, Stéphanie, Aubry, Alexandra, Lascols, Christine, Jarlier, Vincent, Soussy, Claude-James, Cavallo, Jean-Didier, Cambau, Emmanuelle
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Genetics and Molecular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2648189/
https://ncbi.nlm.nih.gov/pubmed/19060136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.01205-08
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