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Structural and mechanistic analysis of ATPase inhibitors targeting mycobacterial DNA gyrase
OBJECTIVES: To evaluate the efficacy of two novel compounds against mycobacteria and determine the molecular basis of their action on DNA gyrase using structural and mechanistic approaches. METHODS: Redx03863 and Redx04739 were tested in antibacterial assays, and also against their target, DNA gyras...
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| Publicado no: | J Antimicrob Chemother |
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| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7556816/ https://ncbi.nlm.nih.gov/pubmed/32728686 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkaa286 |
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