Structural and mechanistic analysis of ATPase inhibitors targeting mycobacterial DNA gyrase

OBJECTIVES: To evaluate the efficacy of two novel compounds against mycobacteria and determine the molecular basis of their action on DNA gyrase using structural and mechanistic approaches. METHODS: Redx03863 and Redx04739 were tested in antibacterial assays, and also against their target, DNA gyras...

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Detalhes bibliográficos
Publicado no:J Antimicrob Chemother
Main Authors: Henderson, Sara R, Stevenson, Clare E M, Malone, Brandon, Zholnerovych, Yelyzaveta, Mitchenall, Lesley A, Pichowicz, Mark, McGarry, David H, Cooper, Ian R, Charrier, Cedric, Salisbury, Anne-Marie, Lawson, David M, Maxwell, Anthony
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7556816/
https://ncbi.nlm.nih.gov/pubmed/32728686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkaa286
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