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Identification of disease treatment mechanisms through the multiscale interactome

Most diseases disrupt multiple proteins, and drugs treat such diseases by restoring the functions of the disrupted proteins. How drugs restore these functions, however, is often unknown as a drug’s therapeutic effects are not limited to the proteins that the drug directly targets. Here, we develop t...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Ruiz, Camilo, Zitnik, Marinka, Leskovec, Jure
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7979814/
https://ncbi.nlm.nih.gov/pubmed/33741907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21770-8
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