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Identification of disease treatment mechanisms through the multiscale interactome

Most diseases disrupt multiple proteins, and drugs treat such diseases by restoring the functions of the disrupted proteins. How drugs restore these functions, however, is often unknown as a drug’s therapeutic effects are not limited to the proteins that the drug directly targets. Here, we develop t...

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Pubblicato in:Nat Commun
Autori principali: Ruiz, Camilo, Zitnik, Marinka, Leskovec, Jure
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2021
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7979814/
https://ncbi.nlm.nih.gov/pubmed/33741907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21770-8
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