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Single-Strand DNA Breaks Cause Replisome Disassembly
DNA damage impedes replication fork progression and threatens genome stability. Upon encounter with most DNA adducts, the replicative CMG helicase (CDC45-MCM2-7-GINS) stalls or uncouples from the point of synthesis, yet eventually resumes replication. However, little is known about the effect on rep...
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| Publicado no: | Mol Cell |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2021
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7979477/ https://ncbi.nlm.nih.gov/pubmed/33484638 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.12.039 |
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