DNA single-strand break-induced DNA damage response causes heart failure

The DNA damage response (DDR) plays a pivotal role in maintaining genome integrity. DNA damage and DDR activation are observed in the failing heart, however, the type of DNA damage and its role in the pathogenesis of heart failure remain elusive. Here we show the critical role of DNA single-strand b...

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Publicado no:Nat Commun
Main Authors: Higo, Tomoaki, Naito, Atsuhiko T., Sumida, Tomokazu, Shibamoto, Masato, Okada, Katsuki, Nomura, Seitaro, Nakagawa, Akito, Yamaguchi, Toshihiro, Sakai, Taku, Hashimoto, Akihito, Kuramoto, Yuki, Ito, Masamichi, Hikoso, Shungo, Akazawa, Hiroshi, Lee, Jong-Kook, Shiojima, Ichiro, McKinnon, Peter J., Sakata, Yasushi, Komuro, Issei
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5413978/
https://ncbi.nlm.nih.gov/pubmed/28436431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15104
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