DNA single-strand break-induced DNA damage response causes heart failure

The DNA damage response (DDR) plays a pivotal role in maintaining genome integrity. DNA damage and DDR activation are observed in the failing heart, however, the type of DNA damage and its role in the pathogenesis of heart failure remain elusive. Here we show the critical role of DNA single-strand b...

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Publicat a:Nat Commun
Autors principals: Higo, Tomoaki, Naito, Atsuhiko T., Sumida, Tomokazu, Shibamoto, Masato, Okada, Katsuki, Nomura, Seitaro, Nakagawa, Akito, Yamaguchi, Toshihiro, Sakai, Taku, Hashimoto, Akihito, Kuramoto, Yuki, Ito, Masamichi, Hikoso, Shungo, Akazawa, Hiroshi, Lee, Jong-Kook, Shiojima, Ichiro, McKinnon, Peter J., Sakata, Yasushi, Komuro, Issei
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5413978/
https://ncbi.nlm.nih.gov/pubmed/28436431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15104
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