A PML/RARα direct target atlas redefines transcriptional deregulation in acute promyelocytic leukemia

Transcriptional deregulation initiated by oncogenic fusion proteins plays a vital role in leukemia. The prevailing view is that the oncogenic fusion protein promyelocytic leukemia/retinoic acid receptor-α (PML/RARα), generated by the chromosome translocation t(15;17), functions as a transcriptional...

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Vydáno v:Blood
Hlavní autoři: Tan, Yun, Wang, Xiaoling, Song, Huan, Zhang, Yi, Zhang, Rongsheng, Li, Shufen, Jin, Wen, Chen, Saijuan, Fang, Hai, Chen, Zhu, Wang, Kankan
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2021
Témata:
Myeloid Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7976511/
https://ncbi.nlm.nih.gov/pubmed/32854112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2020005698
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