Treatment-influenced associations of PML-RARα mutations, FLT3 mutations, and additional chromosome abnormalities in relapsed acute promyelocytic leukemia

Mutations in the all-trans retinoic acid (ATRA)–targeted ligand binding domain of PML-RARα (PRα/LBD(+)) have been implicated in the passive selection of ATRA-resistant acute promyelocytic leukemia clones leading to disease relapse. Among 45 relapse patients from the ATRA/chemotherapy arm of intergro...

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Hauptverfasser: Gallagher, Robert E., Moser, Barry K., Racevskis, Janis, Poiré, Xavier, Bloomfield, Clara D., Carroll, Andrew J., Ketterling, Rhett P., Roulston, Diane, Schachter-Tokarz, Esther, Zhou, Da-cheng, Chen, I-Ming L., Harvey, Richard, Koval, Greg, Sher, Dorie A., Feusner, James H., Tallman, Martin S., Larson, Richard A., Powell, Bayard L., Appelbaum, Frederick R., Paietta, Elisabeth, Willman, Cheryl L., Stock, Wendy
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2012
Schlagworte:
Myeloid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3437597/
https://ncbi.nlm.nih.gov/pubmed/22734072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-01-407601
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