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Trib1 promotes acute myeloid leukemia progression by modulating the transcriptional programs of Hoxa9
The pseudokinase Trib1 functions as a myeloid oncogene that recruits the E3 ubiquitin ligase COP1 to C/EBPα and interacts with MEK1 to enhance extracellular signal-regulated kinase (ERK) phosphorylation. A close genetic effect of Trib1 on Hoxa9 has been observed in myeloid leukemogenesis, where Trib...
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| Pubblicato in: | Blood |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society of Hematology
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7976434/ https://ncbi.nlm.nih.gov/pubmed/32730594 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019004586 |
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